General description
A constituent and psychoactive ingredient of the mushroom Amanita muscariathat acts as a potent agonist of GABAA receptors (EC50 = 28 µM and 33 µM in neonatal and adult rats, respectively), with preferential efficacy and selectivity to high-affinity receptor subtypes. Shown to be permeate the blood-brain barrier. Impairs associate and memory functions.
Biochem/physiol Actions
Primary Target
GABAA
Warning
Toxicity: Toxic (F)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Chandra, D., et al. 2010. Neuropsychopharmacology.35, 999.
Fischer, H., et al. 2005. J. Physiol.564, 465.
Ramirez, D.R., et al. 2005. Neurobiol. Learning and Memory.84, 184.
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Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Shipping Information:
Hazmat Fee: $65.00 + applicable shipping charges are added after the order is placed.
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- UPC:
- 51142562
- Condition:
- New
- Availability:
- 3-5 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- Yes
- MPN:
- 5060440001
- CAS:
- 2763-96-4
