General description
p120 catenin is encoded on chromosome 11q11. Alpha-catenin and beta-catenin bind to the intracellular domain of E-cadherin while p120 catenin binds E-cadherin at a juxta-membrane site. The complex stabilizes tight junctions. In the cell, p120 catenin localized to the E-cadherin/catenins cell adhesion complex, directly associates with cytoplasmic C-terminus of E-cadherin and may similarly interact with other cadherins. A deficiency of E-cadherin results in the intracytoplasmic accumulation of p120 catenin. Lobular carcinoma of the breast shows intracytoplasmic accumulation of p120 catenin while ductal carcinoma shows reduced membrane p120 catenin without cytoplasmic accumulation. In gastric and colonic carcinoma, strong cytoplasmic p120 catenin is associated with discohesive infiltrative morphology.
Quality
IVD | IVD | IVD | RUO |
Linkage
p120 Catenin Positive Control Slides, Product No. 420S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
Physical form
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Preparation Note
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
Other Notes
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
Legal Information
Cell Marque is a trademark of Sigma-Aldrich Co. LLC
biological source: mouse. Quality Level: 100, 500. conjugate: unconjugated. antibody form: culture supernatant. antibody product type: primary antibodies. clone: MRQ-5, monoclonal. description: For In Vitro Diagnostic Use in Select Regions (See Chart). form: buffered aqueous solution. species reactivity: human. packaging: vial of 0.1 . mL concentrate (420M-14), vial of 0.5 . mL concentrate (420M-15), bottle of 1.0 . mL predilute (420M-17), vial of 1.0 . mL concentrate (420M-16), bottle of 7.0 . mL predilute (420M-18). manufacturer/tradename: Cell Marque™. . technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:200. isotype: IgG1. control: lobular breast carcinoma. shipped in: wet ice. storage temp.: 2-8°C. visualization: cytoplasmic. Gene Information: human ... CTNND1(1500).- UPC:
- 51202806
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 420M-10