Application
N-Acetyl-D-sphingosine is a cell-permeable and biologically active ceramide. N-Acetyl-D-sphingosine induces differentiation and apoptosis in cells. N-Acetyl-D-sphingosine produces concentration-dependent impairment of vasorelaxation in response to the endothelium-dependent agonist acetylcholine in nontransgenic mice.
Biochem/physiol Actions
Cell-permeable, biologically active ceramide. It induces differentiation and apoptosis in cells and has been shown to activate protein phosphatases.
Preparation Note
Prepared from D-sphingosine from bovine brain cerebrosides.
Molecular Weight: 341.53. Empirical Formula: C
20H
39NO
3. biological source: semisynthetic. Quality Level: 200. Assay: ≥. 97% (TLC). form: powder. color: white. solubility: DMSO: soluble, ethanol: soluble. lipid type: sphingolipids. storage temp.: −. 20°C. SMILES string: CCCCCCCCCCCCC\C: C\[C@H](O)[C@@H](CO)NC(C): O. InChI: 1S/C20H39NO3/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-20(24)19(17-22)21-18(2)23/h15-16,19-20,22,24H,3-14,17H2,1-2H3,(H,21,23)/b16-15+/t19-,20+/m1/s1. InChI key: BLTCBVOJNNKFKC-HEQKZDDYSA-N. Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: Eyeshields, Gloves, type N95 (US).