N-ACETYL-LLE-GLU-THR-ASP 7-AMIDO-4- METHYLCOUMARIN (C005B-239022)

Amino Acid Sequence

NAc-Ile-Glu-Thr-Asp-AMC

Application

Fluorogenic substrate for caspase 8 and granzyme B.

Molecular Weight: 675.68. Empirical Formula: C₃₁H₄₁N₅O₁₂. Quality Level: 200. Assay: ≥. 97% (HPLC). form: powder. color: white. solubility: DMSO/DMF: 1 . mg/mL. storage temp.: −. 20°C. SMILES string: CC[C@H](C)[C@H](NC(C): O)C(: O)N[C@@H](CCC(O): O)C(: O)N[C@@H]([C@@H](C)O)C(: O)N[C@@H](CC(O): O)C(: O)Nc1ccc2C(C): CC(: O)Oc2c1. InChI: 1S/C31H41N5O12/c1-6-14(2)26(32-17(5)38)30(46)34-20(9-10-23(39)40)28(44)36-27(16(4)37)31(47)35-21(13-24(41)42)29(45)33-18-7-8-19-15(3)11-25(43)48-22(19)12-18/h7-8,11-12,14,16,20-21,26-27,37H,6,9-10,13H2,1-5H3,(H,32,38)(H,33,45)(H,34,46)(H,35,47)(H,36,44)(H,39,40)(H,41,42)/t14-,16+,20-,21-,26-,27-/m0/s1. InChI key: ZYTCBVQZQSFKHQ-HGZCCCDHSA-N. Gene Information: human ... CARD8(22900), CASP8(841), CASP8AP2(9994), CFLAR(8837), GZMB(3002)
mouse ... CFLAR(117279), GZMB(171528)
rat ... CASP8(12370), CFLAR(12633), GZMB(14939), RGD1561819(502004), RGD1562700(502007). Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: Eyeshields, Gloves, type N95 (US).