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n-acetyl-s-(2-amino-9-(4-fluorobenzyl)-6-oxo-6 9-dihydro-1h-purin-8-yl)-l-cysteinefbng p-fluorobenzylguanine ligand autac ligand (c15-1224-187)

N-ACETYL-S-(2-AMINO-9-(4-FLUOROBENZYL)-6-OXO-6 9-DIHYDRO-1H-PURIN-8-YL)-L-CYSTEINEFBNG P-FLUOROBENZYLGUANINE LIGAND AUTAC LIGAND (C15-1224-187)

Sigma-Aldrich

Catalog No.
C15-1224-187
Manufacturer No.
929476-50MG
Manufacturer Name
Sigma-Aldrich
Quantity
50
Unit of Measure
MG
Price: $257.14
List Price: $285.71

Application N -acetyl- S -(2-amino-9-(4-fluorobenzyl)-6-oxo-6,9-dihydro-1 H -purin-8-yl)-L-cysteine is a p -fluorobenzylguanine (FBnG) based ligand used to initiate selective autophagy as a strategy for targeted protein degradation and PROTAC

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Application

N-acetyl-S-(2-amino-9-(4-fluorobenzyl)-6-oxo-6,9-dihydro-1H-purin-8-yl)-L-cysteine is a p-fluorobenzylguanine (FBnG) based ligand used to initiate selective autophagy as a strategy for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology.

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Other Notes

AUTACs: Cargo-Specific Degraders Using Selective Autophagy

Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel-Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7

BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design

Cereblon versus VHL: Hijacking E3 ligases against each other using PROTACs

Systematic exploration of different E3 ubiquitin ligases: an approach towards potent and selective CDK6 degraders

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

UPC:
51473105
Condition:
New
Weight:
1.00 Ounces
HazmatClass:
No
WeightUOM:
LB
MPN:
929476-50MG


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