N-DESETHYL AMODIAQUINE DIHYDROCHLORIDE (C005B-314094)

Catalog No.: C005B-314094
Mfr. No.: SMB00947-5MG
Mfr. Name: Sigma-Aldrich
Qty/UOM: 5
UOM: MG

Price: $359.92

List Price: $399.91

Application Amodiaquine (AQ) is currently used in combination with Artesunate (AS) as first-line treatment for some cases of falciparum malaria (UM) in many countries. AQ is metabolized by hepatic cytochrome P450 2C8 (CYP2C8) to

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Description
Specifications

Application

Amodiaquine (AQ) is currently used in combination with Artesunate (AS) as first-line treatment for some cases of falciparum malaria (UM) in many countries. AQ is metabolized by hepatic cytochrome P450 2C8 (CYP2C8) to Desethylamodiaquine (DAQ; DEAQ; NADQ; Ndes-amo), which is subsequently eliminated via extra-hepatic biotransformation by CYP1A1 and CYP1B1. DEAQ is responsible for the pharmacological activity of AQ (both therapeutic and toxicity) due to its long elimination half-life.

Metabolomics research

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UPC:: 51261601
Condition:: New
Availability:: 3-5 Days
Weight:: 1.00 Ounces
HazmatClass:: No
MPN:: SMB00947-5MG
CAS:: 79049-30-2
Temperature Control Device:: Yes

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