Nω-Nitro-L-arginine (C09-0973-853)

Nω-Nitro-L-arginine displays potent inhibition of NOS with selectivity for NOS1 and NOS3 over NOS2. It has been observed to inhibit endothelial nitric oxide biosynthesis and decrease radical generation of peroxynitrite ions. Other inhibitory effects demonstrated in experiments include blocking brady-kinin-induced relaxation in dog coronary artery strips and suppressing morphine tolerance in mice. N G-Nitro-L-arginine causes significant vasoconstriction and is utilized in studying nitric oxide as a neuronal messenger.ApplicationNω-Nitro-L-arginine has been used:as nitric oxide synthase (NOS) inhibitor, to measure the release of nitric oxide (NO) derivatives in cytochrome c reduction assay to pretreat fiber bundles for contractile studies；as NOS inhibitor to characterize the generation of NO in Taxus yunnanensis cells；as an irreversible inhibitor of the neuronal NO synthase (nNOS) to preincubate swimbladder preparations. Specification: 0.98 MDL Number: MFCD00007033 Molecular Formula: C6H13N5O4 Molecular Weight: 219.2 EC Number: 218-418-9 PubChem CID: 440005 Isomeric SMILES: C(C[C@@H](C(=O)O)N)CN=C(N)N[N+](=O)[O-] Beilstein Registry Number: 1728914 Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/N109208-SCI_a6d9455190526e9ca6c2dd9d3c8b889a.pdf