General description

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

N-Nitrosodiethylamine belongs to the group of toxic nitrosamines, known to show carcinogenic, mutagenic, and hepatotoxic properties. It is formed as a byproduct during food processing, pharmaceutical processing, and water treatment. As a result, they are generally found in water, fish, meat, drug substances, etc.

Application

The CRM can be used as follows:

Simultaneous analysis of N-nitrosodiethanolamine, N-nitrosodiethylamine, triethanolamine, diethanolamine in cosmetic samples using liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS)
Solid phase extraction of N-nitrosodimethylamine and N-nitrosomethylethylamine from eight sartans, ranitidine, and metformin and also the fortified products of these drugs, for quantification by gas chromatography-tandem mass spectrometry (GC-MS/MS)
Multi-residue analysis of seven restricted nitrosamines in two body creams and two shower gel samples by vortex-assisted reversed-phase dispersive liquid-liquid microextraction (VA-RP-DLLME) and liquid chromatography-mass spectrometry (LC-MS)
Quantitative analysis of four nitrosamines in four sartan drug substances— candesartan cilexetil, olmesartan medoxomi, irbesartan, and valsartan, by gas chromatography-tandem mass spectrometry (GC-MS/MS)
Determination of eight volatile nitrosamines in 28 popular meat product samples using ultrasonic solvent extraction combined with solid phase microextraction (SPME) and GC-MS

Other Notes

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.