NAI (C09-0983-996)

Reagent for RNA SHAPE-MaP experiments in live cellsApplication：2-Methylnicotinic acid imidazolide (NAI or mNAI) is an RNA SHAPE probe for live-cell RNA structure profiling. SHAPE -- or selective 2′-hydroxyl acylation analyzed by primer extension -- uses small, electrophilic chemical probes to react with the 2′-hydroxyl group and provides insight to RNA structure and its dynamics in varied cells states or in cells with gene knockouts. It has also been extended to the SHALiPE approach, selective 2′-hydroxyl acylation with lithium ion-based primer extension. Specifications and Purity: 95%. Molecular Formula: C10H9N3O. Molecular Weight: 187.20. PubChem CID: 66563654. Isomeric SMILES: CC1=C(C=CC=N1)C(=O)N2C=CN=C2. Related Document: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/N288069-SCI_ad3383572e93540353f7bf4579f2a0f2.pdf.