NANOFABTX(TM) - AZIDE LIPID MIX; FOR SYNTHESIS OF AZIDE-FUNCTIONALIZED LIPOSOMES (C005B-254206)

Application

The NanoFabTx^™ Azide Lipid Mix is a ready-to-use nanoformulation lipid mixture for the synthesis of azide-functionalized liposomes, which can be used for targeting and immunotherapy applications, and small molecule encapsulation.

This product is a curated lyophilized lipid mixture of rationally selected lipids in precise ratios that have been optimized to achieve a desired size range of liposomes. Step-by-step protocols for the synthesis azide-functionalized liposomes by extrusion and microfluidics are included. The synthesized azide-functionalized liposomes enables the conjugation of DBCO or alkyne-modified antibodies, proteins, aptamers, or other molecules to the liposomes surface which can be used for multi-targeting or multi-type cargo delivery to difference cell types including immune cells.

Features and Benefits

• A ready-to-use nanoformulation lipid blend to synthesize azide-functionalized liposomes
• Step-by-step protocols developed and tested by our formulation scientists
• Flexible synthesis tool to create uniform and reproducible liposomes
• Optimized to make liposomes around 100 nm with low polydispersity
• Optimized lipid blend for DBCO-modified protein or antibody conjugation
• Optimized lipid blend for azide-functionalized liposomes for small molecule encapsulation

For microfluidic liposome synthesis of azide-functionalized liposomes, the NanoFabTx^™- Azide Lipid Mix can be used with the the NanoFabTx^™ Microfluidic - nano device kit (Cat.No. 911593). The NanoFabTx^™ Microfluidic - nano device kit includes the microfluidics chips, fittings, and tubing required to get started with microfluidics-based synthesis (compatible microfluidics system or syringe pump required).

Legal Information

NANOFABTX is a trademark of Sigma-Aldrich Co. LLC

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