NANOFABTX(TM)-DC-CHOL LIPID MIX; FOR SYNTHESIS OF CATIONIC (DC-CHOLESTEROL) LIPOSOMES (C15-1313-262)

General description

NanoFabTx^™-DC-Chol Lipid Mix; for synthesis of cationic (DC-cholesterol) liposomes is a ready-to-use nanoformulation blend for the synthesis of liposomes for drug delivery. The NanoFabTx^™-DC-Chol Lipid Mix includes optimized protocols with step-by-step instructions for synthesizing cationic DC-cholesterol liposomes for drug delivery applications. The modification of the liposomes with the cationic lipid, DC-cholesterol, have numerous advantages including high gene transfection efficiency. Liposome-based formulations are widely used for drug delivery applications and enable improved therapeutic efficacy of a range of drug types including small molecules, nucleic acids, proteins, and peptides.

Application

About NanoFabTx^™

NanoFabTx^™ lipid mixes and formulation kits enable users to encapsulate a wide variety of therapuetic drug molecules for targeted or extended drug delivery without the need for lengthy trial-and-error optimization. NanoFabTx^™ reagent kits provide an easy-to-use toolkit for encapsulating a variety of therapeutics in nanoparticles, microparticles, or liposomes. Drug encapsulated particles synthesized with the NanoFabTx^™ kits are suitable for biomedical research applications such as oncology, immuno-oncology, gene delivery, and vaccine delivery.

Features and Benefits

• A ready-to-use nanoformulation blend for the synthesis of cationic DC-cholesterol liposomes
• Step-by-step protocols (extrusion or microfluidic) developed and tested by our formulation scientists
• Flexible synthesis tools to create uniform and reproducible liposomes
• Optimized to make liposomes around 100 nm with low polydispersity
• DC-Cholesterol allows for high transfection efficiency and targeted drug delivery

Comprehensive protocols for liposome synthesis are included:

• A lipid film hydration and extrusion protocol.
• A microfluidics protocol using commercial platforms or syringe pumps.

The microfluidics protocol included with this product uses the NanoFabTx^™ device kit (911593). These kits are ready-to-use and include the microfluidic chip, fittings, and tubing required for microfluidics-based synthesis (compatible microfluidics system or syringe pump required).

Legal Information

NANOFABTX is a trademark of Sigma-Aldrich Co. LLC

Quality Level: 100. storage temp.: −. 20°C. Storage Class Code: 11 - Combustible Solids. WGK: WGK 3.