NANOFABTX(TM) FLASHNANO - PEG LIPID MIX FOR CIJ SYNTHESIS OF PEGYLATED LIPOSOMES

Application

NanoFabTx^™ NanoFlash PEG Lipid Mix a ready-to-use nanoformulation lipid blend that includes lyophilized lipids and step-by-step instructions for synthesizing PEGylated liposomes for small molecule drug delivery applications. Lipid-based formulations are widely used for drug delivery and enable improved therapeutic efficacy of a range of drug types PEGylated liposomes are capable of encapsulating both hydrophilic and lipophilic compounds and are an effective mechanism to increase the efficiency of drug delivery by prolonging the lifetime of the drug-encapsulated liposome.
This lipid mix has been curated and designed for flash nanoprecipitiaton (FNP) synthesis using a confined impingement jet (CIJ) mixer, such as the NanoFabTx^™ NanoFlash CIJ Mixer, and detailed step-by-step instructions are provided.

Features and Benefits

• A ready-to-use nanoformulation lipid blend for the synthesis of PEGylated liposomes
• Step-by-step protocols (extrusion and microfluidics) developed and tested by our formulation scientists
• Flexible synthesis tool to create uniform and reproducible liposomes
• Optimized to make liposomes around 100 nm with low polydispersity
• Optimized lipid blend for stealth PEGylated liposomes for small molecule encapsulation

The NanoFabTx^™- PEG Lipid Mix provides reagents and protocols for extrusion and microfluidics to synthesize liposomes for drug delivery research application. This reagent kit can be combined with the NanoFabTx^™ Microfluidic - nano device kit (Cat.No. 91153) for microfluidic synthesis of PEGylated liposomes. Comprehensive protocols for liposome synthesis are included:

• A lipid film hydration and extrusion protocol
• A microfluidics protocol using commercial platforms or syringe pumps

The microfluidics protocol included with this product uses the NanoFabTx^™ device kit (911593). These kits come with the microfluidics chips, fittings, and tubing required to get started with microfluidics-based synthesis (compatible microfluidics system or syringe pump required).

Legal Information

NANOFABTX is a trademark of Sigma-Aldrich Co. LLC

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