NCX 470 (C09-1157-387)

NCX 470 is a second-generation nitric oxide (NO)-donating prostaglandin analogue. NCX 470 effectively lowers intraocular pressure (IOP) in animal models of ocular hypertension and glaucoma by activating bimatoprost-mediated uveoscleral outflow and NO mediated conventional outflow. NCX 470 can be used for the research of cular hypertension and glaucoma.In VivoNCX 470 shows a better intraocular pressure-lowering efficacy than that of equimolar doses of bimatoprost in well-established animal models of glaucoma and ocular hypertension . NCX 470 (0.14% 30 μL; instillation; once) reduces IOP in transient ocular hypertensive rabbits. NCX 470 (0.042% 30 μL; instillation; once) is more effective than equimolar bimatoprost in cynomolgus monkeys with laser-induced ocular hypertension (OHT-monkeys), and normotensive dogs (ONT-dogs) at 18 hours post dosing. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: New Zealand white rabbits with 0.1 mL 5% sodium chloride solution injectionDosage: 0.14% Administration: Instillation; 0.14% 30 μL; once Result: Significantly blunted the IOP rise throughout the experimental period in transiently ocular hypertensive New Zealand white rabbits.Form:Oil. Specification: 0.98 Molecular Formula: C31H46N2O8 Molecular Weight: 574.71 PubChem CID: 44462739 Isomeric SMILES: CCNC(=O)CCC/C=C/C[C@H]1[C@H](C[C@H]([C@@H]1/C=C/[C@H](CCC2=CC=CC=C2)OC(=O)CCCCCO[N+](=O)[O-])O)O