NE 52-QQ57 (C007B-392139)

InformationNE 52-QQ57 is a selective, and orally available antagonist ofG-protein coupled receptor 4 (GPR4)with IC50 of 0.07 μM. NE 52-QQ57 effectively blocks GPR4-mediated cAMP accumulation with IC50 of 26.8 nM in HEK293 cells. The antagonism of GPR4 with NE 52-QQ57 significantly inhibits the AGE-induced increased expression of several key inflammatory cytokines and signaling molecules, includingtumor necrosis factor-α (TNF-α),interleukin (IL)-1β,IL-6,inducible nitricTargetsTNF-α ; IL-1β ; IL-6 ; iNOS ; NO 33706,;. Specification: 0.98 Molecular Formula: C24H28N6O Molecular Weight: 416.52 PubChem CID: 68379135 Isomeric SMILES: CCC1=NN2C(=CC(=NC2=C1CC3=CC=C(C=C3)C4=NN=C(O4)C5CCNCC5)C)C Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/N413659-SCI_cf1d6f672e212765d862614837b12e8f.pdf