NG-497 (C005B-308562)

Catalog No.: C005B-308562
Mfr. No.: SML3712-5MG
Mfr. Name: Sigma-Aldrich
Qty/UOM: 1
UOM: EA

Price: $304.24

List Price: $338.05

Biochem/physiol Actions NG-497 is a non-cytotoxic, substrate-competitive, reversible and highly selective human/primate adipose triglyceride lipase (ATGL: IPLA2-zeta: PNPLA2) inhibitor (IC50 = 1 μ:M, Ki = 0.5 μ:M) with little activity

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Biochem/physiol Actions

NG-497 is a non-cytotoxic, substrate-competitive, reversible and highly selective human/primate adipose triglyceride lipase (ATGL; IPLA2-zeta; PNPLA2) inhibitor (IC50 = 1 μM, Ki = 0.5 μM) with little activity toward related human lipid hydrolases or ATGL orthologues from other species (<20% inhibition of mouse, rat, goat, pig, dog, marmoset ATGL at 50 μM). NG-497 abolishes hormone-induced lipolysis in human adipocytes (IC50 = 1.5 and 0.5 μM against 1 μM isoproterenol-induced total or hormonesensitive lipase (HSL)-independent FA release in Simpson-Golabi-Behmel syndrome adipocytes), but not in HepG2 that lacks ATGL hydrolase activity.

UPC:: 51323105
Condition:: New
Availability:: 3-5 Days
Weight:: 1.00 Ounces
HazmatClass:: No
MPN:: SML3712-5MG
CAS:: 2598242-66-9

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