NG-Monomethyl-L-arginine Acetate (C007B-238727)

L-NG-Monomethylarginine, Acetate Salt (L-NMMA), is an analogue of L-arginine that has been shown to inhibit Ca2+-dependent NOS3 (endothelial NOS) from porcine aorta. In an experiment on porcine aortic rings, L-NMMA was shown to cause contraction and inhibition of the endothelium-dependent relaxation induced by acetylcholine. This compound has also been noted to elicit a dose-dependent increase in mean systemic arterial blood pressure accompanied by bradycardia. Experiments on cat vascular endothelia show that L-NMMA can increase leukocyte adherence and emigration and reduce venular shear rate. Low shear rates have been shown to promote platelet-endothelial and leukocyte-endothelial cell adhesion in mesenteric venules. L-NG-Monomethylarginine, Acetate Salt (L-NMMA) is an inhibitor of NOS1 and NOS2.An L-arginine analogue inhibitor of Ca2+-dependent NOS3 (endothelial NOS). Specification: ≥98% MDL Number: MFCD00069311 Molecular Formula: C7H16N4O2·C2H4O2 Molecular Weight: 248.28 PubChem CID: 135242 Isomeric SMILES: CC(=O)O.CN=C(N)NCCC[C@@H](C(=O)O)N Beilstein Registry Number: 6674260 Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/N133898-SCI_f51486c43a483e1963293aaf4c26c92f.pdf