NINTEDANIB (C005B-310006)

Catalog No.: C005B-310006
Mfr. No.: SML2848-5MG
Mfr. Name: Sigma-Aldrich
Qty/UOM: 5
UOM: MG

Price: $192.78

List Price: $214.20

Biochem/physiol Actions Nintedanib (BIBF1120) is an orally active, potent ATP-competitive inhibitor against angiokinases VEGFR-1/2/3 (IC 50 = 34/21/13 nM), FGFR-1/2/3/4 (IC 50 = 69/37/108/610 nM), PDGFRα:/β: (IC 50 = 59/65 nM), as well

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Description
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Biochem/physiol Actions

Nintedanib (BIBF1120) is an orally active, potent ATP-competitive inhibitor against angiokinases VEGFR-1/2/3 (IC₅₀ = 34/21/13 nM), FGFR-1/2/3/4 (IC₅₀ = 69/37/108/610 nM), PDGFRα/β (IC₅₀ = 59/65 nM), as well as Flt-3, Lck, Lyn, and Src (IC₅₀ = 26, 16, 195, 156 nM, repectively), but not 33 other kinases. Nintedanib exhibits antiangiogenic and antifibrotic efficacy in cultures and in animal models of cancers and pulmonary fibrosis in vivo.

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UPC:: 51111862
Condition:: New
Availability:: 3-5 Days
Weight:: 1.00 Ounces
HazmatClass:: Yes
MPN:: SML2848-5MG
CAS:: 656247-17-5

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