NO-Indomethacin is a hybrid molecule of indomethacin and a nitric oxide (NO) donor. This design combines the anti-inflammatory and Cox -1 and -2 inhibitory properties of indomethacin with the gastrointestinal protective effects of NO. Compounds of this class retain their anti-inflammatory and analgesic activity, but have reduced gastrointestinal and kidney toxicity compared to indomethacin alone. NO-Indomethacin also enhances the cancer chemopreventative activity of indomethacin. NO-indomethacin exhibits an IC|50|of 82 μM, compared to >1,000 μM for indomethacin alone, for the inhibition of pancreatic cancer cell (PaCa-2) growth after 24 hours in culture. Molecular Formula: C28H30ClN3O9S Molecular Weight: 620.07 PubChem CID: 9830512 Isomeric SMILES: CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)SC[C@@H](C(=O)OCCCCO[N+](=O)[O-])NC(=O)C Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/N332142-SCI_39b930cad9a835f5905f505583c6b53a.pdf
- UPC:
- 12352101
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 0.96 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- N332142-5mg
- CAS:
- 301838-28-8
- Product Size:
- 5mg
- Hazard Statement Codes:
- H319:H336
- Precautionary Statement Codes:
- P261:P264:P271:P280
