NOVASYN TG SIEBER RESIN 1 G (C15-1310-474)

General description

NovaSyn TG Sieber resin consists of 130 μm NovaSyn TG bromo resin derivatized with Sieber′s xanhydrylamine linker ^[1,2]. This resin is ideal for the Fmoc SPPS of partially protected peptide amide fragments. Cleavage from this support is effected by treatment with 1% TFA in DCM, conditions that leave most standard side-chain protecting groups intact. This resin can be reductively alkylated and used to prepare secondary carboxamides ^[3]. It can also be employed to produce protected peptide fragments in which the C-terminal carboxylic acid group is blocked as a hydroxymethylphenoxy-β-alaninamide ester ^[4].

Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins

Literature references

^[1] P. Sieber (1987) Tetrahedron Lett., 28, 2107.
^[2] C. Somlai, et al. in ′Peptides 1992, Proc.22nd European Peptide Symposium′, C. H. Schneider & A. N. Eberle (Eds), ESCOM, Leiden, 1993, pp. 198.
^[3] W. C. Chan, et al. (1995) J. Chem. Soc., Chem. Commun., 1475.
^[4] W. C. Chan, et al. (1995) J. Chem. Soc., Chem. Commun., 589.

Linkage

Replaces: 01-64-0092

Analysis Note

Color (visual): light yellow to yellow to beige
Appearance of substance (visual): beads
Loading (Photometric determination of the Fmoc-chromophore liberated upon treatment with DBU/DMF): 0.10 - 0.25 mmol/g
Swelling Volume (in DMF): lot specific result
The polymer matrix is NovaSyn TG resin (130µm)

Legal Information

NOVASYN is a registered trademark of Merck KGaA, Darmstadt, Germany

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Quality Level: 200. product line: NovaSyn^®. TG, Novabiochem^®. . form: beads. reaction suitability: reaction type: Fmoc solid-phase peptide synthesis. manufacturer/tradename: Novabiochem^®. . application(s): peptide synthesis. functional group: amine. storage temp.: 2-8°C. Storage Class Code: 11 - Combustible Solids. WGK: WGK 1. Flash Point(F): Not applicable. Flash Point(C): Not applicable.