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nps2143 hydrochloride (c15-1725-303)

NPS2143 HYDROCHLORIDE (C005B-313463)

Catalog No.
C005B-313463
Mfr. No.
SML0362-25MG
Mfr. Name
Sigma-Aldrich
Qty/UOM
25
UOM
MG
Price: $1,214.35
List Price: $1,349.27

Application NPS2143 hydrochloride has been used to study the function of calcium-sensing receptor : In the regulation of intestinal calcium transport. In the regulation of local negative feedback of intestinal calcium absorption.

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Application

NPS2143 hydrochloride has been used to study the function of calcium-sensing receptor :

  • In the regulation of intestinal calcium transport.
  • In the regulation of local negative feedback of intestinal calcium absorption.
  • In sensorimotor decision making during development.

Biochem/physiol Actions

NPS2143 is a phenylalkylamine calcilytic compound, and might be useful in treating autosomal dominant hypocalcemia. It serves as a blocking agent for hERG (human ether-a-go-go-related gene ) channel, CYP2D6 (cytochrome P450 2D6 ) and monoamine transporters.

NPS2143 is a selective calcium-sensing receptor (CaR) antagonist. The compound blocks increases in cytoplasmic calcium concentrations with an IC50 of 43 nM, and stimulates parathyroid hormone (PTH) secretion from bovine parathyroid cells over a wide range of extracellular calcuim concentrations.

UPC:
51172453
Condition:
New
Availability:
3-5 Days
Weight:
1.00 Ounces
HazmatClass:
No
MPN:
SML0362-25MG
CAS:
324523-20-8

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