Immunogen: peptide from the N-terminal region of human Nrf-2 Host: rabbit Species Reactivity: (+) human, mouse, and rat Nrf2 Application(s): FC, ICC, and WB This N-terminal Nrf2 polyclonal antibody detects both poly-ubiquitinated Nrf2 at 90 kDa and native Nrf2 at 67 kDa. Nrf2 forms a heterodimer with a small Maf protein and binds to the antioxidant response element in the upstream promoter region of many antioxidative genes. Under normal, unstressed conditions, Nrf2 is sequestered in the cytoplasm where it is bound by Keap1 and cullin 3. Certain stressors disrupt Keap 1 binding and prevent ubiquitination, leading to subsequent translocation into the nucleus.
- UPC:
- 12350000
- Condition:
- New
- Availability:
- 3 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 14114-1
