Celecoxib is a non-steroidal anti-inflammatory drug (NSAID) that inhibits COX-2; it exhibits anti-inflammatory, analgesic, anticancer, and anti-metastatic activities. Celecoxib is clinically used to treat arthritis, acute pain, and ankylosing spondylitis. In hepatoma cells, celecoxib decreases the mitochondrial membrane potential, increases cytochrome c release, activates caspases 3 and 9, alters Bcl-2 and Bax levels, and induces apoptosis. In vitro, celecoxib inhibits release of IL-6, IL-1β, and MIP-1α, suppresses phosphorylation of JNK, and activates SIRT1. Additionally, this compound inhibits invasion and migration of nasopharyngeal carcinoma cells by decreasing activity of matrix metalloproteinases 2 and 9 (MMP2/9). Grade: ≥98%
- UPC:
- 41122409
- Condition:
- New
- Availability:
- 3 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- C1644-100 mg
- CAS:
- 169590-42-5
