NSC 23766 is a specific inhibitor of the binding and activation of RAC GTPase. In vitro studies have shown that NSC 23766 inhibits Rac 1 binding and activation via Rac-specific GEF Trio or Tiam 1 without altering RhoA or Cdc42 binding or activation. Membrane type 1-matrix metalloproteinases (MT-1MMP) expression in CB CD34+ cells has been reported to decrease in the presence of NSC 23766. Silveta compressa investigations indicate that NSC 23766 depolarizes endomembrane cycling, altered polar adhesive secretion, and tip growth. NSC 23766 is also known as Rac1 Inhibitor, NSC23766, NSC-23766, 6-N-[2-[5-(diethylamino)pentan-2-ylamino]-6-methylpyrimidin-4-yl]-2-methylquinoline-4,6-diamine trihydrochloride, and N6-[2-[[4-(Diethylamino)-1-methylbutyl]amino]-6-methyl-4-pyrimidinyl]-2-methyl-4,6-quinolinediamine trihydrochloride. Specification: ≥95% Molecular Formula: C24H35N7•3HCl Molecular Weight: 530.96 PubChem CID: 409805 Isomeric SMILES: CCN(CC)CCCC(C)NC1=NC(=CC(=N1)NC2=CC3=C(C=C(N=C3C=C2)C)N)C Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/N331803-SCI_38482cc9c89e7e114a33493f779419e3.pdf
- UPC:
- 51183707
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 0.96 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- N331803-10mg
- CAS:
- 733767-34-5
- Product Size:
- 10mg
- Precautionary Statement Codes:
- P264
