InformationNSC59984 NSC59984 is a p53 pathway activator via induction of mutant p53 protein degradation and p73 activation.Targetsp53In vitroNSC59984 specifically restores p53 pathway signaling and induces p73-dependent cell death in mutant p53-expressing human colorectal cancer cells. NSC59984 also induces cell death in a panel of cancer cell lines bearing different p53 mutations with little or no genotoxicity in normal cells.In vivoIn nude mice bearing DLD-1 xenograft tumors, NSC59984 (45 mg/kg, i.p.) significantly represses tumor growth in a p73-dependent manner.Cell Research(from reference)Cell lines：SW480, DLD-1, HCT116, p53- HCT116, MRC5, Hop92, RXF393 and Wi38 cells Concentrations：~100 μM Incubation Time：72 h. Specification: 10mM in DMSO Molecular Formula: C12H15N3O4 Molecular Weight: 265.27 PubChem CID: 5356520 Isomeric SMILES: CN1CCN(CC1)C(=O)/C=C/C2=CC=C(O2)[N+](=O)[O-]
- UPC:
- 51111863
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 0.85 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- N426078-1ml
- CAS:
- 803647-40-7
- Product Size:
- 1ml
