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NT157 (C09-0990-487)

Aladdin

Catalog No.
C09-0990-487
Manufacturer No.
N408053-1ml
Manufacturer Name
Aladdin Scientific
Quantity
1
Unit of Measure
EA
Price: $1,048.68
List Price: $1,165.20

InformationNT157 NT157, a selective inhibitor of IRS-1/2(insulin receptor substrate) , has the potential to inhibit IGF-1R and STAT3 signaling pathways in cancer cells and stroma cells of TME leading to a decrease in cancer cell

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InformationNT157 NT157, a selective inhibitor of IRS-1/2(insulin receptor substrate) , has the potential to inhibit IGF-1R and STAT3 signaling pathways in cancer cells and stroma cells of TME leading to a decrease in cancer cell survival.In vitroNT157 treatment resulted in dose-dependent inhibition of IGF1R activation, suppression of IRS protein expression, inhibition of IGF1-induced AKT activation, but increased ERK activation in NT157-treated cells in vitro. These effects were correlated with decreased proliferation and increasing apoptosis of LNCaP cells and increasing G2-M arrest in PC3 cells. NT157 can mediate suppression of IGF1R-mediated survival signaling through the established mechanism for negative feedback of IGF1R signaling: targeting IRS1/2 for serine phosphorylation and subsequent degradation. NT157 displayed little to no effect on the survival of normal melanocytes and fibroblasts.In vivoNT157 suppressed androgen-responsive growth, delayed CRPC progression of LNCaP xenografts, and suppressed PC3 tumor growth alone and in combination with docetaxel. Melanoma tumor growth and metastasis is efficiently inhibited by NT157.Cell Datacell lines:Concentrations:0-10 μMIncubation Time:72 hPowder Purity:≥98%. Specification: 10mM in DMSO Molecular Formula: C16H14BrNO5S Molecular Weight: 412.26
UPC:
12352005
Condition:
New
Availability:
8-12 weeks
Weight:
0.85 Ounces
HazmatClass:
No
WeightUOM:
LB
MPN:
N408053-1ml
CAS:
1384426-12-3
Product Size:
1ml


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