Okadaic Acid, Potassium Salt

Okadaic Acid, Potassium Salt is a water-soluble analog of Okadaic Acid, isolated from cultured|Prorocentrum concavum|. The salt form is generated in aqueous potassium hydroxide methanol solution. The compound is a potent inhibitor of serine/threonine-specific protein phosphatases PP1, PP2A, 5534, PP2C and endogenous phosphatase smooth muscle myosin at IC|50|of 10-15 nM, 0.1 nM, 5 μM, >10 μM and 15-70 nM respectively. This inhibition action has been used to stimulate the activity of glucose transport and has been observed to block insulin's stimulation of glucose transport by inhibiting IRS-1 phosphorylation. Okadaic Acid, Potassium Salt has been used as a response modifier in the study of large granular lymphocyte and T-cell biochemistry. In addition to inhibitive activities it is a tumor promoter and has been used to study nitric oxide metabolism, apoptosis, cell cycle and calcium signaling. Specification: 0.98 Molecular Formula: C44H67O13•K Molecular Weight: 843.1 PubChem CID: 44134868 Isomeric SMILES: CC1CCC2(CCCCO2)OC1C(C)CC(C3C(=C)C(C4C(O3)CCC5(O4)CCC(O5)C=CC(C)C6CC(=CC7(O6)C(CCC(O7)CC(C)(C(=O)[O-])O)O)C)O)O.[K+] Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/O338097-SCI_144ae743c753fc836cd6ed9592c434f9.pdf