Oligomycin A from Streptomyces diastatochromogenes (C09-0993-404)

Oligomycin A inhibits ATP5 (mitochondrial ATPases, F1F0) bound to the cell membrane. This compound stimulates lysosome acidification due to shunting of membrane potential at a concentration of 1.5-3 μM. The compound has been observed to Induce apoptosis in a variety of cell types along with inducing a switch from the apoptotic to necrotic pathway. It also exhibits broad nematocidal, antifungal, and antitumor activities. Oligomycin A has caused dissipated mitochondrial membrane potential, decreased cytoplasmic ATP contents and disassembled metaphase II oocyte spindles when introduced to mouse oocytes.Oligomycin is used to inhibit membrane bount mitochondrial ATP synthase. It is used to inhibit sucrose synthesis and 14C translocation in sunflower leaves, to study antibiotic resistance, and to study carotid chemoreceptor responses to O2 and CO2 in the cat. Specification: ≥97% MDL Number: MFCD00065705 Molecular Formula: C45H74O11 Molecular Weight: 791.06 EC Number: 209-437-3 PubChem CID: 5281899 Isomeric SMILES: CC[C@H]/1CC[C@@H]2[C@@H]([C@@H]([C@H]([C@@]3(O2)CC[C@H]([C@H](O3)C[C@H](C)O)C)C)OC(=O)/C=C/[C@H]([C@@H]([C@H](C(=O)[C@H]([C@@H]([C@H](C(=O)[C@@]([C@@H]([C@H](C/C=C/C=C1)C)O)(C)O)C)O)C)C)O)C)C Beilstein Registry Number: 5702132 Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/O102388-SCI_02ea104fda8e86584931997afda2c1f2.pdf