OPHIOBOLIN A (C005B-312052)

Catalog No.: C005B-312052
Mfr. No.: SML1478-1MG
Mfr. Name: Sigma-Aldrich
Qty/UOM: 1
UOM: MG

Price: $707.28

List Price: $785.86

Biochem/physiol Actions Ophiobolin A is a fungal metabolite, toxic to many crops and found to have antimicrobial and anticancer activity. Ophiobolin A is a calmodulin antagonist and inhibitor of big conductance Ca2+-activated K+ channel (BKCa)

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Biochem/physiol Actions

Ophiobolin A is a fungal metabolite, toxic to many crops and found to have antimicrobial and anticancer activity. Ophiobolin A is a calmodulin antagonist and inhibitor of big conductance Ca2+-activated K+ channel (BKCa) activity. Its anticancer activity may involve inhibition of multiple oncogenic signaling pathways including PI3K/mTOR, Ras/Raf/ERK and CDK/RB. One study suggested the possibility of pyrrolylation of lysine residues on its intracellular target protein(s) as a mechanism of action on various targets.

Other Notes

Light and air sensitive.

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UPC:: 51302600
Condition:: New
Availability:: 3-5 Days
Weight:: 1.00 Ounces
HazmatClass:: Yes
MPN:: SML1478-1MG
CAS:: 990299

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