OSS_128167 (C09-0998-022)

InformationOSS_128167 (SIRT6-IN-1) is a specificSIRT6inhibitor withIC50values of 89, 1578 and 751 μM for SIRT6, SIRT1 and SIRT2, respectively. OSS_128167 has anti-viral effect in HBV transcription and replication.TargetsSIRT6 (Cell-free); SIRT2 (Cell-free); SIRT1 (Cell-free) 89 μM; 751 μM; 1578 μMIn vitroOSS-128167 is a selective compounds toward SIRT6 with IC50 values toward SIRT1 and SIRT2 being approximately 20 times higher. It is cell permeable and active in cultured cells. OSS-128167 increases H3K9 acetylation and GLUT-1 expression.Cell Research(from reference)Cell lines：BxPC3 cells Concentrations：100 μM Incubation Time：0, 2, 6, 18, 24 h. Specification: 0.99 Molecular Formula: C19H14N2O6 Molecular Weight: 366.32 PubChem CID: 6496840 Isomeric SMILES: C1=CC(=CC(=C1)NC(=O)C2=CC=CO2)C(=O)NC3=CC(=C(C=C3)O)C(=O)O Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/O414086-SCI_ee91452983874be77841856377a66a11.pdf