Oxcarbazepine (C09-0993-434)

Oxcarbazepine (OXC) is the keto-analog of carbamazepine. Unlike carbamazepine, oxcarbazepine has no side effects. It is an antiepileptic drug, with an antineuralgic property. It has a pharmacokinetic advantage over carbamazepine. It is prescribed for neuropathic pain and serves as an effective pain reliever in trigeminal neuralgia.The catabolism of OXC to its monohydroxy derivative has significant pharmacologic property. It modulates potassium channels and voltage-dependent sodium channels. OXC modulates V2 receptor-G protein complex in collecting tubules and is used for treating diabetes insipidus.Oxcarbazepine (GP 47680) inhibits the binding of [3H]BTX to sodium channels with IC50 of 160 μM and also inhibits the influx of 22Na+ into rat brain synaptosomes with IC50 about 100 μM.Oxcarbazepine has been used in reversed-phase high-performance liquid chromatography of human epileptic brain endothelial cells. Specifications and Purity: 98%. MDL Number: MFCD00865307. Molecular Formula: C15H12N2O2. Molecular Weight: 252.27. EC Number: 249-188-8. PubChem CID: 34312. Isomeric SMILES: C1C2=CC=CC=C2N(C3=CC=CC=C3C1=O)C(=O)N. Related Document: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/O104504-SCI_6f6af8c361affcf9bd4373c17f016011.pdf.