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oxidized atp (oatp)

OXIDIZED ATP (OATP)

Sigma-Aldrich

Catalog No.
C15-1259-636
Manufacturer No.
5057580001
Manufacturer Name
Sigma-Aldrich
Quantity
25
Unit of Measure
MG
Price: $444.34
List Price: $493.71

A 2′,3′-dialdehyde derivative of ATP that is commonly used to affinity label nucleotide sites in enzymes. Acts as a specific, irreversible antagonist of P2Z/P2X 7 purinergic receptors in J774 mouse macrophages.

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General description

A 2′,3′-dialdehyde derivative of ATP that is commonly used to affinity label nucleotide sites in enzymes. Acts as a specific, irreversible antagonist of P2Z/P2X7 purinergic receptors in J774 mouse macrophages. Does not affect P2γ receptors. Inhibits inflammatory pain in arthritic rat model by blocking ATP action on P2X7 receptor in nerve terminals. Also shown to irreversibly block ATP-induced Ca2+ influx in lymphocytes (˜100 µM). O-ATP-treated mice display better preservation and lower rate of rejection of pancreatic islet grafts with reduced Th1 transcripts.

Biochem/physiol Actions

Reversible: no

Warning

Toxicity: Standard Handling (A)

Other Notes

Vergani, A., et al. 2013. Diabetes62, 1665.
DellʹAntonio, G., et al. 2002. Arthritis Rheum.46, 3378.
Wiley, J.S., et al. 1994. Br. J. Pharmacol.112, 946.

Murgia, M., et al. 1992. J. Biol. Chem.268, 8199.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

UPC:
51381909
Condition:
New
Weight:
1.00 Ounces
HazmatClass:
No
WeightUOM:
LB
MPN:
5057580001


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