Oxotremorine M iodide is a potent and non-selective muscarinic acetylcholine receptor (mAChR) agonist. Oxotremorine M iodide potentiates NMDA receptors by muscarinic receptor dependent and independent mechanisms.In VitroOxotremorine M iodide (0.1, 0.3, 1, 3, 10, 30 μM) inhibits KCNQ2/3 currents in the concentration-dependence. Oxotremorine M iodide elicits a robust phosphoinositide response characterized with an EC 50 of 0.22 μM. Oxotremorine M iodide has EC 50 s of 0.36, 0.52, 1.62, and 1.48 μM for wild-type, M2, M3, and M2/M3 knockout mice, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only.In VivoOxotremorine M iodide (0.5 mg/kg; s.c.) increases Ddopamine (DA) release in the medial prefrontal cortex (mPFC) and has no effect in the nucleus accumbens (NAC) in male sprague-dawley albino rats weighing 250-350 g. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:Solid. Specifications and Purity: ≥98.0%. Molecular Formula: C11H19IN2O. Molecular Weight: 322.19. PubChem CID: 3027782. Isomeric SMILES: C[N+](C)(C)CC#CCN1CCCC1=O.[I-].
- UPC:
- 12352005
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 1.06 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- O647850-50mg
- CAS:
- 3854-04-4
- Product Size:
- 50mg
