General description
p-Toluenesulfonyl chloride is an organic sulfonyl chloride mainly used to convert hydroxyl groups into good leaving group by forming sulfonates.
Application
p-Toluenesulfonyl chloride may be used in the following processes:
- In combination with N-methylimidazole for the esterification or thioesterification of carboxylic acids and alcohols or thiols.
- As an additive to enhance the yield of symmetrical biaryls via palladium chloride catalyzed homo-coupling of arylboronic acids in the absence of ligands.
- As a positive chlorine source for the ?-chlorination of ketones.
- Solvent-free tosylation of alcohols and phenols in the presence of heterodoxy acids.
- As an activator for reaction between 2-alkynylbenzaldoxime and phenols to form 1-aroxyisoquinolines in the presence of silver triflate.
- As a catalyst for the solvent-free preparation of symmetrical bis(benzhydryl)ethers from benzhydrols.
Legal Information
ReagentPlus is a registered trademark of Sigma-Aldrich Co. LLC
- UPC:
- 51392802
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 240877-500G
