General description
p-Toluenesulfonylmethyl isocyanide undergoes base-promoted 1,3-dipolar cycloaddition reaction with immobilized imines under microwave irradiation to yield 1,5-disubstituted imidazoles. It is a versatile synthon in organic chemistry, extensively used for the synthesis of heterocyclic compounds.
Application
p-Toluenesulfonylmethyl isocyanide was used:
- in the synthesis of triplet drugs with the 1,3,5-trioxazatriquinane skeleton
- as reagent in the preparation of biologically active pyrroles and imidazoles
- as the isonitrile component in a diastereoselective Passerini reaction employing sugar-derived aldehydes
- UPC:
- 51101614
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 188204-5G