p53 Activator 7 is a p53 mutation Y220C (MDM-2/p53) activator with an EC 50 of 104 nM. p53 Activator 7 can bind to p53 mutant and restore its ability to bind DNA (WO2022213975A1; Example B-1)In VitroThe p53 protein, referred to as the “guardian of the human genome” , is a tetrameric transcription factor that prevents mutation to the genome by regulating the expression of a subgroup of target genes. Although biologically active as a homotetramer, each p53 monomer is comprised of 393 amino acids, and is divided into five key regulatory domains: the transactivation domain (TAD) , proline-rich region (PR) , the DNA binding domain (DBD) , the oligomerization domain (OD) , and the C-terminus. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:EC50: 104 nM (p53 mutation Y220C). Specification: 0.98 Molecular Formula: C27H32F3N4OP Molecular Weight: 516.54
- UPC:
- 51342906
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 1.06 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- P646987-5mg
- CAS:
- 2849340-59-4
- Product Size:
- 5mg
