PAMAM-OH dendrimer, generation 6 solution (C15-1305-267)

General description

PAMAM-OH (poly(amidoamine) dendrimers are highly branched core-shell nanostructures with surface hydroxyl groups. The presence of hydroxyl groups on the surface of the PAMAM-OH dendrimer molecule leads to stronger interaction with the components of the cell membrane via the formation of hydrogen bonds. This type of interaction can modify the properties and function of cell membranes. PAMAM-OH dendrimers also have an advantage over PAMAM dendrimers in terms of cytotoxicity and aggregation problems because of the absence of amine functionality.

Application

PAMAM-OH dendrimer can be used to formulate poorly water-soluble drugs to increase water solubility, and therefore enhance the bioavailability of these drugs. It can also be applied to catalysts and organic molecules, where dendrimers function as solubility enhancers and modifiers.

Physical form

Contains 256 surface hydroxyl groups.

Legal Information

Manufactured by Dendritech^®, Inc.

Dendritech is a registered trademark of Dendritech, Inc.

Molecular Weight: 58298.21. Empirical Formula: C₂₅₄₂H₄₈₃₂N₇₆₂O₇₆₄. linearFormula: [NH₂(CH₂)₂NH₂]:(G: 6). dendri PAMAM(NHCH₂CH₂OH)₂₅₆. description: amidoethanol surface groups. Quality Level: 100. form: liquid. mol wt: generation 6. feature: core type ethylenediamine core (2-carbon core). concentration: 5 . wt. % in methanol. no. Surface Groups: 256. refractive index: n20/D 1.336. density: 0.807 . g/mL . at 25 . °C. storage temp.: 2-8°C. Pictograms: GHS02,GHS06,GHS08. Signal Word: Danger. Hazard Statements: H225 - H301 + H311 + H331 - H370. Precautionary Statements: P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311. Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1. Target Organs: Eyes. Storage Class Code: 3 - Flammable liquids. WGK: WGK 3. Flash Point(F): 51.8 °F - closed cup. Flash Point(C): 11 °C - closed cup.