PD-118057 is a potent ether associated (hERG) potassium channel activator that shows no activity against hERG. PD-118057 inhibits the excitability of the membrane by activating the hERG channel. PD-118057 is a potential compound for the treatment of delayed repolarization in inherited or acquired long QT syndrome and congestive heart failure.PD-118057 (3 μM and 10 μM) specifically increases hERG current and inhibits action potential duration in guinea pig ventricular muscle in acute isolation of guinea pig cardiomyocytes.PD-118057 (10 μM) counteracts the current inhibition triggered by Dof and Mox while preserving the unaltered 'hump' shape of the IKr current and exhibiting only a marginal increase in the maximum value of the suppressed current.
Specifictaions: Moligand™, ≥97%
MDL Number: C₂₁H₁₇Cl₂NO₂
Molecular Formula: 386.27
PubChem CID: 9864959
Isomeric SMILES: C1=CC=C(C(=C1)C(=O)O)NC2=CC=C(C=C2)CCC3=CC(=C(C=C3)Cl)Cl
Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/P286627-SCI_e1fa0ebe57662ef27e7210671553e0eb.pdf
- UPC:
- 41106200
- Condition:
- New
- Availability:
- 4-8 weeks
- Weight:
- 1.23 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- P286627-5mg
- CAS:
- 313674-97-4
- Product Size:
- 5mg
- Hazard Statement Codes:
- H413;H335;H319;H315
- Precautionary Statement Codes:
- P319;P332+P317;P337+P317;P264+P265;P362+P364;P403+P233;P304+P340;P271;P264;P501;P405;P321;P302+P352;P280;P273;P305+P351+P338;P261
