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PERTUSSIS TOXIN FROM BORDETELLA PERTUSSIS SOLUTION IN 50% MM TRIS 10 MM GLYCERINE 0.5 M NACL PH 7.5 (C005B-439920)

Catalog No.
C005B-439920
Mfr. No.
P2980-.2MG
Mfr. Name
Sigma-Aldrich
Qty/UOM
0.2
UOM
MG
Price: $3,902.10
List Price: $4,335.66

Application The toxin is released from B. pertussis in an inactive form.

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Application

The toxin is released from B. pertussis in an inactive form. When the pertussis toxin B oligomer binds to the cell membrane, the S1 subunit of its A protomer becomes activated, perhaps through the action of glutathione and ATP. A protocol for activating pertussis toxin in vitro is given by Kaslow, et al.

Biochem/physiol Actions

Pertussis toxin catalyzes the ADP-ribosylation of the α subunits of the heterotrimeric guanine nucleotide regulatory proteins Gi, Go, and Gt. This prevents the G protein heterotrimers from interacting with receptors, thus blocking their coupling and activation. Since the Gα subunits remain in their GDP-bound, inactive state, they are unable to inactivate adenylyl cyclase or open K+ channels.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Physical form

Aseptically filled solution in 50% glycerol, containing 50 mM TRIS, 10 mM glycine, 0.5 M NaCl, pH 7.5

Shipping Information:

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UPC:
51201647
Condition:
New
Availability:
3-5 Days
Weight:
1.00 Ounces
HazmatClass:
No
MPN:
P2980-.2MG
CAS:
70323-44-3
Temperature Control Device:
Yes

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