PF-05085727 (C005B-432462)

Catalog No.: C005B-432462
Mfr. No.: PZ0355-5MG
Mfr. Name: Sigma-Aldrich
Qty/UOM: 5
UOM: MG

Price: $253.46

List Price: $281.62

Biochem/physiol Actions PF-05085727 is a potent inhibitor against cGMP-dependent phosphodiesterase PDE2 (PDE2A: IC50 = 2.3 nM) with >:500-fold selectivity over other PDEs.

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Biochem/physiol Actions

PF-05085727 is a potent inhibitor against cGMP-dependent phosphodiesterase PDE2 (PDE2A; IC50 = 2.3 nM) with >500-fold selectivity over other PDEs. Its 3-[(18)F]fluoroazetidinyl derivative ([(18)F]PF-05270430) has been successfully applied via i.v. injection as a brain-permeant probe for imaging brain PDE2 in live cynomolgus monkeys by positron emission tomography (PET).

Legal Information

Sold for research purposes under agreement from Pfizer Inc.

Pfizer is a registered trademark of Pfizer, Inc.

UPC:: 51142029
Condition:: New
Availability:: 3-5 Days
Weight:: 1.00 Ounces
HazmatClass:: No
MPN:: PZ0355-5MG
CAS:: 1415637-72-7

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