PF-06747711 is a potent, selective, and orally active retinoic acid receptor-related orphan C2 ( RORC2 , also known as RORγt ) inverse agonist, with an IC 50 of 4.1 nM. Anti-skin inflammatory activityIn VitroPF-06747711 (Compound 66) reduces IL-17 production by human Th17 cells with an IC 50 of 9.5 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.In VivoPF-06747711 (10, 30, and 100 mg/kg, p.o., daily over 5 days) inhibits ear swelling in a dose-dependent manner in mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: 8−10 week old female Balb/c mice Dosage: 10, 30, and 100 mg/kg Administration: P.O. daily over 5 days Result: Inhibited ear swelling, and caused a maximum inhibition of 46% at 100 mg/kg.Form:SolidIC50& Target:IC50: 4.1 nM (RORC2). Specification: 0.99 Molecular Formula: C26H26F3N5O2 Molecular Weight: 497.51 PubChem CID: 118977746 Isomeric SMILES: CC(C)C(=O)N1CCC(CC1)C2=CN(C3=NC=C(C(=C23)C(F)(F)F)NC(=O)C4=CC=CC(=C4)C#N)C
- UPC:
- 51241400
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 1.06 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- P646837-100mg
- CAS:
- 1892576-58-7
- Product Size:
- 100mg
