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PF-06752469 (C15-1848-242)

Sigma Aldrich

Catalog No.
C15-1848-242
Manufacturer No.
PZ0417-25MG
Manufacturer Name
Sigma-Aldrich
Quantity
25
Unit of Measure
MG
Price: $527.14
List Price: $585.71

Biochem/physiol Actions PF-06752469 (PF-6752469) is an orally active, non-cytotoxic (300 μ:M, HepG2), potent and selective ketohexokinase (KHK) inhibitor (human KHK-A/C IC50 = 390/450 nM: rat KHK IC50 = 340 nM) with no significant activity

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Biochem/physiol Actions

PF-06752469 (PF-6752469) is an orally active, non-cytotoxic (300 μM, HepG2), potent and selective ketohexokinase (KHK) inhibitor (human KHK-A/C IC50 = 390/450 nM; rat KHK IC50 = 340 nM) with no significant activity against a broad panel of transporters, receptors, ion channels, and enzymes, including hERG and human CYP450s. PF-06752469 prevents fructose administration-induced fructose 1-phosphate (F1P) upregulation (hepatic/renal ED50 = 15.7/30.0 mg/kg p.o. 2 min prior to 500 mg fructose/10 mL/kg i.v. in rats) by inhibiting KHK-mediated fructose metabolism in vivo.

UPC:
51283709
Condition:
New
Availability:
3-5 Days
Weight:
1.00 Ounces
HazmatClass:
No
WeightUOM:
LB
MPN:
PZ0417-25MG
Product Size:
25/MG
CAS:
2135304-43-5

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