PF-5006739 is a potent and selective inhibitor of CK1δ/ε with IC50s of 3.9 nM and 17.0 nM, respectively. PF-5006739 is a potential therapeutic agent for a range of psychiatric disorders with low nanomolar in vitro potency for CK1δ/ε and high kinome selectivity. PF-5006739 attenuats opioid agent-seeking behavior in a rodent operant reinstatement model in animals in a dose-dependent manner. PF-5006739 improves glucose tolerance in both diet-induced obesity (DIO) and genetic (ob/ob) mice models of obesity. Specification: 0.98 Molecular Formula: C₂₂H₂₂FN₇O Molecular Weight: 419.46 PubChem CID: 51353555 Isomeric SMILES: C1CN(CCC1N2C=NC(=C2C3=NC(=NC=C3)N)C4=CC=C(C=C4)F)CC5=NOC=C5 Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/P288881-SCI_c13a4e51c9d974c6551f2f14ec80df85.pdf
- UPC:
- 51183706
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 1.06 Ounces
- HazmatClass:
- Yes
- WeightUOM:
- LB
- MPN:
- P288881-10mg
- CAS:
- 1293395-67-1
- Health Hazards:
- Toxic
- Product Size:
- 10mg
- Hazard Statement Codes:
- H301
- Precautionary Statement Codes:
- P501:P405:P330:P321:P301:P270:P264
