PF-915275 (C005B-432405)

Catalog No.: C005B-432405
Mfr. No.: PZ0400-5MG
Mfr. Name: Sigma-Aldrich
Qty/UOM: 5
UOM: MG

Price: $234.68

List Price: $260.76

Biochem/physiol Actions PF-915275 is an orally active, potent and selective 11beta-hydroxysteroid dehydrogenase type 1 (11ÃƒÅ¸-HSD1, HSD11B1) inhibitor (human 11ÃƒÅ¸-HSD1 Ki <:1 nM: cellular IC 50 = 5 nM using human 11ÃƒÅ¸-HSD1-transfected HEK293

Enjoy exclusive benefits including discounted pricing on orders by contacting our Sales Executives to open an account. Contact Us

Current Stock:

Quantity:

Adding to cart… The item has been added

Description
Specifications

Biochem/physiol Actions

PF-915275 is an orally active, potent and selective 11beta-hydroxysteroid dehydrogenase type 1 (11ÃƒÅ¸-HSD1, HSD11B1) inhibitor (human 11ÃƒÅ¸-HSD1 Ki <1 nM; cellular IC₅₀ = 5 nM using human 11ÃƒÅ¸-HSD1-transfected HEK293) with reduced potency toward non-human species (human/monkey/dog hepatocytes EC₅₀ = 20/100/120 nM; mouse 11ÃƒÅ¸-HSD1 Ki = 750 nM, rat hepatoma EC50 = 14 μM). PF-915275 (0.1-3-mg/kg via nasogastric intubations) inhibits prednisone-to-prednisolone conversion in cynomolgus monkeys (by 87% with 3 mg/kg) in vivo and reduces plasma insulin increase following prednisone & resumed feeding (4 hrs post PF-915275) among overnight fasted monkeys.

Legal Information

Sold for research purposes under agreement from Pfizer Inc.

UPC:: 51422101
Condition:: New
Availability:: 3-5 Days
Weight:: 1.00 Ounces
HazmatClass:: No
MPN:: PZ0400-5MG
CAS:: 857290-04-1

Cenmed Satisfaction Guarantee

At Cenmed, your confidence and satisfaction are paramount. We guarantee the quality and reliability of our extensive range of clinical and laboratory supplies. If you're not completely satisfied with your purchase, we offer a straightforward return process and dedicated support to resolve your concerns promptly. Our commitment ensures that you can order with confidence, knowing that Cenmed is dedicated to superior service and customer satisfaction. Trust us to meet your needs with every order, backed by our promise of excellence. Learn more in Help & FAQs.

"Cenmed provides me access to the same products/services normally reserved for much larger labs than mine. I was presently surprised by their product offering."