A potent inhibitor of mPGES-1 (IC50 = 16.5 nM for recombinant human enzyme) blocks the synthesis of PGE2 in LPS-treated human whole blood and in IL-1&beta-stimulated fibroblasts (IC50s = 0.4-5 µM).
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A potent inhibitor of mPGES-1 (IC50 = 16.5 nM for recombinant human enzyme); blocks the synthesis of PGE2 in LPS-treated human whole blood and in IL-1β-stimulated fibroblasts (IC50s = 0.4-5 µM).
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