PF-9366 (C15-1848-253)

Sigma Aldrich

Catalog No.: C15-1848-253
Manufacturer No.: PZ0403-5MG
Manufacturer Name: Sigma-Aldrich
Quantity: 5
Unit of Measure: MG

Price: $207.43

List Price: $230.48

Biochem/physiol Actions PF-9366 is a methionine adenosyltransferase 2A allosteric inhibitor (human Mat2A IC 50 /K d = 420 nM/170 nM) whose binding site overlaps with that of the Mat2A regulator, Mat2B. PF-9366 inhibits cellular SAM production in

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Biochem/physiol Actions

PF-9366 is a methionine adenosyltransferase 2A allosteric inhibitor (human Mat2A IC₅₀/K_d = 420 nM/170 nM) whose binding site overlaps with that of the Mat2A regulator, Mat2B. PF-9366 inhibits cellular SAM production in a Mat2B-competitive manner (IC₅₀ post 6-hr treatment = 1.2 μM wihout vs. 0.86 μM with Mat2B knockdown; H520 lung carcinoma cells) without antiproliferation efficacy in cancer cultures due to an induction of Mat2A upregulation upon allosteric inhibition. Similar to Mat2B, PF-9366 allosteric binding alters Mat2A active site, causing increased substrate affinity and decreased enzyme turnover.

Legal Information

Sold for research purposes under agreement from Pfizer Inc.

UPC:: 42191708
Condition:: New
Availability:: 3-5 Days
Weight:: 1.00 Ounces
HazmatClass:: No
WeightUOM:: LB
MPN:: PZ0403-5MG
Product Size:: 5/MG
CAS:: 72882-78-1

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