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PF-9366 (C15-1848-254)

Sigma Aldrich

Catalog No.
C15-1848-254
Manufacturer No.
PZ0403-25MG
Manufacturer Name
Sigma-Aldrich
Quantity
25
Unit of Measure
MG
Price: $672.00
List Price: $746.67

Biochem/physiol Actions PF-9366 is a methionine adenosyltransferase 2A allosteric inhibitor (human Mat2A IC 50 /K d = 420 nM/170 nM) whose binding site overlaps with that of the Mat2A regulator, Mat2B. PF-9366 inhibits cellular SAM production in

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Biochem/physiol Actions

PF-9366 is a methionine adenosyltransferase 2A allosteric inhibitor (human Mat2A IC50/Kd = 420 nM/170 nM) whose binding site overlaps with that of the Mat2A regulator, Mat2B. PF-9366 inhibits cellular SAM production in a Mat2B-competitive manner (IC50 post 6-hr treatment = 1.2 μM wihout vs. 0.86 μM with Mat2B knockdown; H520 lung carcinoma cells) without antiproliferation efficacy in cancer cultures due to an induction of Mat2A upregulation upon allosteric inhibition. Similar to Mat2B, PF-9366 allosteric binding alters Mat2A active site, causing increased substrate affinity and decreased enzyme turnover.

Legal Information

Sold for research purposes under agreement from Pfizer Inc.

UPC:
42191708
Condition:
New
Availability:
3-5 Days
Weight:
1.00 Ounces
HazmatClass:
No
WeightUOM:
LB
MPN:
PZ0403-25MG
Product Size:
25/MG
CAS:
72882-78-1

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