General description
Phosgene is used as a reagent in organic synthesis for various reactions such as carbonylation reaction and synthesis of isocyanates. Phosgene is formed during the free radical induced degradation of chlorinated hydrocarbons. Determination of phosgene in air samples using thermal desorption (TD) followed by gas chromatography-mass spectrometry (GC-MS) has been reported.
Application
Phosgene solution (15 wt. % in toluene) has been used to synthesize the following peptide monomers:
- γ-(4-propargyloxybenzyl)-
L -glutamic acid N-carboxyanhydride (POB-L -Glu-NCA) - γ-(4,5-dimethoxy-2-nitrobenzyl)-
L -glutamate N-carboxyanhydride (DMNB-L -Glu-NCA) - γ-(4,5-dimethoxy-2-nitrobenzyl)-
D -glutamate N-carboxyanhydride (DMNB-D -Glu-NCA) - 2-nitrobenzyl(4-vinylphenyl)carbamate
Phosgene solution may be used in the synthesis of:
- sulfonyl chlorides
- Fmoc (Fluorenylmethyloxycarbonyl chloride)-taurylsulfonyl chloride
- O-benzyl-L-serine carboxyanhydrides
Packaging
The 25 mL Sure/Seal™ bottle is recommended as a single-use bottle. Repeated punctures will likely result in decreased performance of product.
Legal Information
Sure/Seal is a trademark of Sigma-Aldrich Co. LLC
- UPC:
- 12161500
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 748684-4X25ML