Phosphodiesterase I from Crotalus adamanteus, 100u

Phosphodiesterase I successively hydrolyzes 5'-mononucleotides from 3'-hydroxy-terminated ribo- and deoxyribo-oligonucleotides. ADP-ribosylated proteins are cleaved at the pyrophosphate linkages by venom phosphodiesterases to yield phosphoribosyl-AMP. Enzyme that is used to break phosphodiester bonds Membrane-bound glycoprotein Catalyze the hydrolysis of various nucleotide polyphosphates Phosphodiesterase I is used in phosphodiesterase activation assays to hydrolyze AMP. The enzyme has been widely utilized as a tool for structural and sequence studies of nucleic acids. Phosphodiesterase I breaks phosphodiester bonds and catalyzes the hydrolysis of various nucleotide polyphosphates. Phosphodiesterase I is released from eucaryotic plasma membranes by phosphatidylinositol-specific phospholipase C.