PHPS1 sodium salt is a phenylhydrazonopyrazolone sulfonate, which is cell-permeable and inhibits the phosphatase and cellular activities of Shp2. The inhibition of Shp2 effects cellular events such as hepatocyte growth factor/scatter factor (HGF/SF)-induced epithelial cell scattering, branching morphogenesis, and downstream signaling such as paxillin dephosphorylation. Studies have revealed that PHPS1 sodium salt interacts with the active site of Shp2 via forming a seven hydrogen bond lattice between the sulfonate moiety and the PTP signature loop of the enzyme. Specification: ≥98% Molecular Formula: C21H14N5O6S•xNa Molecular Weight: 487.42 Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/P331818-SCI_7d73580302de6e4998a4fe789439d426.pdf
- UPC:
- 12141806
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 0.96 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- P331818-5mg
- CAS:
- 314291-83-3
- Product Size:
- 5mg
- Precautionary Statement Codes:
- P264
