PIKfyve-IN-1 is a highly potent and cell-active chemical probe that inhibits phosphatidylinositol-3phosphate 5-kinase (PIKfyve) with IC 50 value of 6.9 nM. PIKfyve-IN-1 can be used for the research of PIKfyve in virologyIn VitroPIKfyve-IN-1 inhibits PIKfyve in PIKfyve enzymatic assay and PIKfyve NanoBRET assay with IC 50 values of 6.9 nM and 4.01 nM, respectively. PIKfyve-IN-1 (0-10 μM) disrupts multiple phases of the lifecycle of coronaviruses: viral replication and viral entry. PIKfyve-IN-1 inhibits MHV replication and SARS-CoV-2 replication with IC 50 values of 23.5 nM and 19.5 nM, respectively. PIKfyve-IN-1 (5 μM) impacts lysosomal homeostasis. MCE has not independently confirmed the accuracy of these methods. They are for reference only. ImmunofluorescenceCell Line: Calu-3 cells Concentration: 1 μM Incubation Time: 1 h Result: Inhibited the uptake of lentivirus pseudotyped with the SARS-CoV-2 spike glycoprotein.Form:SolidIC50& Target:IC50: 6.9 nM (PIKfyve). Specification: 0.95 Molecular Formula: C20H21N5 Molecular Weight: 331.41
- UPC:
- 51343505
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 1.06 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- P650468-5mg
- CAS:
- 2857982-26-2
- Product Size:
- 5mg
